Draken-The main villain of Episode 4, "Felons and Dragons." He kidnaps Princess Tedina and King Grizulon wants the Cooper Gang to rescue her.Aquillio-The main villain of Episode 3, "Secrets in the Sky." He kidnaps Dimitri's ex-wife, Rita, but she is later rescued by Dimitri during an underwater showdown with Aquillio.He used to be a war commander before starting his crime spree. Commander Ralf-The main villain of Episode 2, "Good War Hunting." He returns in Episode 7 to get revenge on the Cooper Gang.Vladim-The main villain of Episode 1, "The Big Creep." It is revealed during the boss fight, that he picked on Sir Raleigh during their years in high school.
He appears as a boss in the prelude, Episode 1, Episode 3, Episode 5, Episode 7, and Episode 8. Fake Sly-The secondary antagonist of the game.
Raticus and the previous 7 villains the Cooper Gang fought in the last 7 episodes. In the last episode, he forms the "Evil Eight" gang. He is known as the "Master of Thieves" and wants to get rid of the Cooper Gang. She is playable after the "Shootout Showdown" mission in Episode 2.